InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mttp

Summary

InnateDB Gene

IDBG-196207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mttp

Gene Name

microsomal triglyceride transfer protein

Synonyms

1810043K16Rik; MTP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028158

Encoded Proteins

IDBP-196209

microsomal triglyceride transfer protein

IDBP-196211

microsomal triglyceride transfer protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138823:
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:138089855-138143388

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029805	ENSMUSP00000029805
ENSMUST00000098580	ENSMUSP00000096179

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0034185	apolipoprotein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006497	protein lipidation
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0051592	response to calcium ion

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016323	basolateral plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane
GO:0031988	membrane-bounded vesicle
GO:0043235	receptor complex