Mus musculus Gene: Mttp
Summary
InnateDB Gene IDBG-196207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mttp
Gene Name microsomal triglyceride transfer protein
Synonyms 1810043K16Rik; MTP;
Species Mus musculus
Ensembl Gene ENSMUSG00000028158
Encoded Proteins
microsomal triglyceride transfer protein
microsomal triglyceride transfer protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138823:
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:138089855-138143388
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000029805 ENSMUSP00000029805
ENSMUST00000098580 ENSMUSP00000096179
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0034185 apolipoprotein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006497 protein lipidation
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0042953 lipoprotein transport
GO:0051592 response to calcium ion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016323 basolateral plasma membrane
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
GO:0031988 membrane-bounded vesicle
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Chylomicron-mediated lipid transport pathway
Lipoprotein metabolism pathway
KEGG
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Lipoprotein metabolism pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Chylomicron-mediated lipid transport pathway
Chylomicron-mediated lipid transport pathway
Lipoprotein metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
KEGG
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2941 Mm.470777
RefSeq NM_001163457 NM_008642 XM_006501102 XM_006501103
OMIM
CCDS CCDS38650 CCDS51080
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas