Version 5.4
Mus musculus Gene: Smarcc2
Summary
InnateDB Gene IDBG-197552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smarcc2
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms 5930405J04Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000025369
Encoded Proteins
IDBP-197554
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-197556
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-271311
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139613:
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128459236-128490173
Strand Forward strand
Band D3
Transcripts
ENSMUST00000099131 ENSMUSP00000096734
ENSMUST00000026433 ENSMUSP00000026433
ENSMUST00000105235 ENSMUSP00000100868
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0043044 ATP-dependent chromatin remodeling
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0017053 transcriptional repressor complex
GO:0043234 protein complex
GO:0071564 npBAF complex
GO:0071565 nBAF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139613
View Gene Order
ENSBTAG00000014697
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_244207
RMTs methylate histone arginines pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.417338 Mm.473618
RefSeq NM_001114096 NM_001114097 NM_198160 XM_006514022
OMIM
CCDS CCDS24278 CCDS48726 CCDS48727
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca