Bos taurus Gene: GLUL
Summary
InnateDB Gene IDBG-637016.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLUL
Gene Name Glutamine synthetase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013631
Encoded Proteins
Glutamine synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135821:
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:64948332-64958885
Strand Reverse strand
Band
Transcripts
ENSBTAT00000038488 ENSBTAP00000038301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004351 glutamate decarboxylase activity
GO:0004356 glutamate-ammonia ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016874 ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0006542 glutamine biosynthetic process
GO:0006807 nitrogen compound metabolic process
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
GO:0097386 glial cell projection
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Astrocytic Glutamate-Glutamine Uptake And Metabolism pathway
Transmission across Chemical Synapses pathway
Neurotransmitter uptake and Metabolism In Glial Cells pathway
Neuronal System pathway
Metabolism pathway
Amino acid synthesis and interconversion (transamination) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Neuronal System pathway
Neurotransmitter uptake and Metabolism In Glial Cells pathway
Amino acid synthesis and interconversion (transamination) pathway
Metabolism of amino acids and derivatives pathway
Astrocytic Glutamate-Glutamine Uptake And Metabolism pathway
Transmission across Chemical Synapses pathway
Metabolism pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Astrocytic Glutamate-Glutamine Uptake And Metabolism pathway
Neurotransmitter uptake and Metabolism In Glial Cells pathway
Neuronal System pathway
Amino acid synthesis and interconversion (transamination) pathway
Transmission across Chemical Synapses pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Nitrogen metabolism pathway
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Nitrogen metabolism pathway
INOH
Glutamate Glutamine metabolism pathway
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P15103
TrEMBL B3VK57
UniProt Splice Variant
Entrez Gene 281199
UniGene Bt.106825
RefSeq NM_001040474 XM_005217263 XM_005217264
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY186585 BC103099 EU753243 J03604 Y10347
GenPept AAA87357 AAI03100 AAO27470 ACE88260 CAA71373
RNA Seq Atlas 281199
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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