Version 5.4
Mus musculus Gene: Pard3
Summary
InnateDB Gene IDBG-200951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pard3
Gene Name par-3 (partitioning defective 3) homolog (C. elegans)
Synonyms AA960621; AI256638; ASIP; D8Ertd580e; PAR-3; Par3; Pard3a
Species Mus musculus
Ensembl Gene ENSMUSG00000025812
Encoded Proteins
IDBP-200953
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-200955
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-263864
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-541280
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-533019
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-539165
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-536442
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-542250
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-534002
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-537833
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-535420
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-537363
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-536541
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-533937
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-533997
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-532154
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-537732
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-541556
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-532867
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-536561
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-538608
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-539821
par-3 (partitioning defective 3) homolog (C. elegans)
IDBP-538444
par-3 (partitioning defective 3) homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24244864
[Homo sapiens] Atypical PKC and PARD3 are inhibitors of the canonical NF-κB activation pathway in epithelial cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148498:
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:127063893-127612286
Strand Forward strand
Band E2
Transcripts
ENSMUST00000026921 ENSMUSP00000026921
ENSMUST00000079777 ENSMUSP00000078710
ENSMUST00000108752 ENSMUSP00000104383
ENSMUST00000162309 ENSMUSP00000124282
ENSMUST00000160272 ENSMUSP00000125453
ENSMUST00000162907 ENSMUSP00000124319
ENSMUST00000160593
ENSMUST00000162536 ENSMUSP00000125212
ENSMUST00000159141 ENSMUSP00000124733
ENSMUST00000159818 ENSMUSP00000124339
ENSMUST00000162665 ENSMUSP00000124718
ENSMUST00000160766 ENSMUSP00000124533
ENSMUST00000162602 ENSMUSP00000125450
ENSMUST00000162531 ENSMUSP00000125610
ENSMUST00000160581 ENSMUSP00000124141
ENSMUST00000161355 ENSMUSP00000125064
ENSMUST00000159537 ENSMUSP00000124934
ENSMUST00000161277 ENSMUSP00000124789
ENSMUST00000160717 ENSMUSP00000125612
ENSMUST00000162456 ENSMUSP00000124162
ENSMUST00000162035
ENSMUST00000162176 ENSMUSP00000123944
ENSMUST00000163021
ENSMUST00000162727 ENSMUSP00000124359
ENSMUST00000161348 ENSMUSP00000123951
ENSMUST00000163002
ENSMUST00000159511 ENSMUSP00000124441
ENSMUST00000159940
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0019903 protein phosphatase binding
GO:0032266 phosphatidylinositol-3-phosphate binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0003383 apical constriction
GO:0006612 protein targeting to membrane
GO:0007049 cell cycle
GO:0007163 establishment or maintenance of cell polarity
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0016337 single organismal cell-cell adhesion
GO:0022011 myelination in peripheral nervous system
GO:0031643 positive regulation of myelination
GO:0032970 regulation of actin filament-based process
GO:0044319 wound healing, spreading of cells
GO:0051301 cell division
GO:0051642 centrosome localization
GO:0060341 regulation of cellular localization
GO:0070830 tight junction assembly
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030054 cell junction
GO:0033269 internode region of axon
GO:0043025 neuronal cell body
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0043234 protein complex
GO:0044295 axonal growth cone
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148498
View Gene Order
ENSBTAG00000014991
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_248094
Cell-cell junction organization pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_196549
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_241978
Cell junction organization pathway
REACT_236746
Tight junction interactions pathway
REACT_223082
Cell-Cell communication pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04530
Tight junction pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04520
Adherens junction pathway
mmu04062
Chemokine signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_19373
Tight junction interactions pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_19331
Cell-cell junction organization pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04520
Adherens junction pathway
hsa04530
Tight junction pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.299254 Mm.481890
RefSeq NM_001013580 NM_001013581 NM_001122850 NM_033620 XM_006531520 XM_006531521 XM_006531522 XM_006531523 XM_006531524 XM_006531525 XM_006531527 XM_006531528 XM_006531529 XM_006531530 XM_006531531 XM_006531533
OMIM
CCDS CCDS22788 CCDS22789 CCDS40523 CCDS52712
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca