Mus musculus Gene: Echs1
Summary
InnateDB Gene IDBG-211665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Echs1
Gene Name enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Synonyms C80529;
Species Mus musculus
Ensembl Gene ENSMUSG00000025465
Encoded Proteins
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127884:
The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:140105710-140116476
Strand Reverse strand
Band F4
Transcripts
ENSMUST00000026538 ENSMUSP00000026538
ENSMUST00000155647
ENSMUST00000135842 ENSMUSP00000121174
ENSMUST00000151505
ENSMUST00000147643
ENSMUST00000125337
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005515 protein binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Metabolism pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Metabolism of lipids and lipoproteins pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
KEGG
Fatty acid elongation pathway
Fatty acid degradation pathway
Valine, leucine and isoleucine degradation pathway
Lysine degradation pathway
Tryptophan metabolism pathway
beta-Alanine metabolism pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
Metabolism pathway
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Metabolism of lipids and lipoproteins pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
Metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
KEGG
Fatty acid elongation pathway
Fatty acid degradation pathway
Valine, leucine and isoleucine degradation pathway
Lysine degradation pathway
Tryptophan metabolism pathway
beta-Alanine metabolism pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
INOH
Lysine degradation pathway
Tryptophan degradation pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24452 Mm.402648 Mm.408900
RefSeq NM_053119
OMIM
CCDS CCDS21964
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas