Bos taurus Gene: TFAP2C
Summary
InnateDB Gene IDBG-641326.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFAP2C
Gene Name transcription factor AP-2 gamma
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002065
Encoded Proteins
transcription factor AP-2 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087510:
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:59903160-59912715
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002671 ENSBTAP00000002671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0001942 hair follicle development
GO:0003334 keratinocyte development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008584 male gonad development
GO:0019827 stem cell maintenance
GO:0021877 forebrain neuron fate commitment
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030718 germ-line stem cell maintenance
GO:0035019 somatic stem cell maintenance
GO:0043588 skin development
GO:0045682 regulation of epidermis development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048733 sebaceous gland development
GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.32640 Bt.69920
RefSeq NM_001075509 XM_005214648 XM_005214649
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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