InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TFAP2C

Summary

InnateDB Gene

IDBG-641326.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFAP2C

Gene Name

transcription factor AP-2 gamma

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002065

Encoded Proteins

IDBP-693678

transcription factor AP-2 gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087510:
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:59903160-59912715

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002671

ENSBTAP00000002671

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0001942	hair follicle development
GO:0003334	keratinocyte development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008584	male gonad development
GO:0019827	stem cell maintenance
GO:0021877	forebrain neuron fate commitment
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030718	germ-line stem cell maintenance
GO:0035019	somatic stem cell maintenance
GO:0043588	skin development
GO:0045682	regulation of epidermis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048733	sebaceous gland development
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000087510

View Gene Order

ENSMUSG00000028640

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

tap63pathway

Validated transcriptional targets of TAp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.32640 Bt.69920

RefSeq

NM_001075509 XM_005214648 XM_005214649

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas