Homo sapiens Gene: TFAP2C
Summary
InnateDB Gene IDBG-81995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFAP2C
Gene Name transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Synonyms AP2-GAMMA; ERF1; hAP-2g; TFAP2G;
Species Homo sapiens
Ensembl Gene ENSG00000087510
Encoded Proteins
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:56629302-56639283
Strand Forward strand
Band q13.31
Transcripts
ENST00000201031 ENSP00000201031
ENST00000416606 ENSP00000390857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
Experimentally validated
Total 93 [view]
Protein-Protein 86 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0001942 hair follicle development
GO:0003334 keratinocyte development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0008584 male gonad development
GO:0019827 stem cell maintenance
GO:0021877 forebrain neuron fate commitment
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030718 germ-line stem cell maintenance
GO:0035019 somatic stem cell maintenance
GO:0043588 skin development
GO:0045682 regulation of epidermis development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048733 sebaceous gland development
GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.473152
RefSeq NM_003222
HUGO
OMIM
CCDS CCDS13454
HPRD 03361
IMGT
EMBL
GenPept
RNA Seq Atlas