Mus musculus Gene: Oprl1
Summary
InnateDB Gene IDBG-214226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oprl1
Gene Name opioid receptor-like 1
Synonyms KOR-3; KOR3; LC132; MOR-C; morc; Oprl; ORGC; ORL1; XOR1;
Species Mus musculus
Ensembl Gene ENSMUSG00000027584
Encoded Proteins
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
opioid receptor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125510:
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181715016-181720985
Strand Forward strand
Band H4
Transcripts
ENSMUST00000071585 ENSMUSP00000071513
ENSMUST00000108768 ENSMUSP00000104399
ENSMUST00000108767 ENSMUSP00000104398
ENSMUST00000108766 ENSMUSP00000104397
ENSMUST00000108763 ENSMUSP00000104394
ENSMUST00000148334 ENSMUSP00000118664
ENSMUST00000126835
ENSMUST00000151241
ENSMUST00000183693 ENSMUSP00000138810
ENSMUST00000184795 ENSMUSP00000138979
ENSMUST00000184127 ENSMUSP00000139119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001626 nociceptin receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007610 behavior
GO:0019233 sensory perception of pain
GO:0038003 opioid receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P35377
TrEMBL
UniProt Splice Variant
Entrez Gene 18389
UniGene
RefSeq NM_001252565 NM_011012 XM_006500582 XM_006500583 XM_006500584
OMIM
CCDS CCDS17222
HPRD
IMGT
MGI ID MGI:97440
MGI Symbol Oprl1
EMBL AF043276 AF043277 AF043278 AF062381 AF075605 AF126469 BC050885 D31667 U04952 U09421 U14165 U32928 U32930 U32932 X91813
GenPept AAA03730 AAA81333 AAA87899 AAC52669 AAC64507 AAC64508 AAC64509 AAF21258 AAF21781 AAH50885 AAL54889 BAA06509 CAA62922
RNA Seq Atlas 18389