Homo sapiens Gene: RGS20
Summary
InnateDB Gene IDBG-21786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS20
Gene Name regulator of G-protein signaling 20
Synonyms g(z)GAP; gz-GAP; RGSZ1; ZGAP1;
Species Homo sapiens
Ensembl Gene ENSG00000147509
Encoded Proteins
regulator of G-protein signaling 20
regulator of G-protein signaling 20
regulator of G-protein signaling 20
regulator of G-protein signaling 20
regulator of G-protein signaling 20
regulator of G-protein signaling 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:53851808-53959303
Strand Forward strand
Band q11.23
Transcripts
ENST00000297313 ENSP00000297313
ENST00000344277 ENSP00000344630
ENST00000276500 ENSP00000276500
ENST00000517659 ENSP00000428795
ENST00000523280 ENSP00000429897
ENST00000518286
ENST00000523414
ENST00000522225 ENSP00000430627
ENST00000523064
ENST00000517405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
G alpha (z) signalling events pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O76081
TrEMBL B3KSW4
UniProt Splice Variant
Entrez Gene 8601
UniGene Hs.368733 Hs.741492
RefSeq NM_001286673 NM_170587 NM_001286675 NM_001286674 NM_003702
HUGO HGNC:14600
OMIM 607193
CCDS CCDS69482 CCDS6155 CCDS6156
HPRD 06225
IMGT
EMBL AC100821 AC113194 AF060877 AF074979 AF366054 AF366055 AF366056 AF366057 AF493940 AK094503 AY046538 BC015614 BC063490
GenPept AAC62009 AAC62013 AAH15614 AAH63490 AAK54122 AAK54123 AAK54124 AAK54125 AAL03971 AAM12654 BAG52876
RNA Seq Atlas 8601