Version 5.4
Homo sapiens Gene: EXOG
Summary
InnateDB Gene IDBG-26030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOG
Gene Name endo/exonuclease (5'-3'), endonuclease G-like
Synonyms ENDOGL1; ENDOGL2; ENGL; ENGL-a; ENGL-b; ENGLA; ENGLB;
Species Homo sapiens
Ensembl Gene ENSG00000157036
Encoded Proteins
IDBP-26034
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372159
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372187
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372188
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372189
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372190
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372192
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372195
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372199
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372205
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372206
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-372212
endo/exonuclease (5'-3'), endonuclease G-like
IDBP-484259
endo/exonuclease (5'-3'), endonuclease G-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
This gene encodes an endo/exonuclease with 5\'-3\' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5\' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:38496127-38542161
Strand Forward strand
Band p22.2
Transcripts
ENST00000287675 ENSP00000287675
ENST00000412107 ENSP00000400239
ENST00000422077 ENSP00000404305
ENST00000436414 ENSP00000413176
ENST00000443942 ENSP00000412841
ENST00000431472 ENSP00000394977
ENST00000447573 ENSP00000406101
ENST00000454803 ENSP00000412756
ENST00000457367 ENSP00000402164
ENST00000438992 ENSP00000407641
ENST00000453767 ENSP00000397124
ENST00000450732 ENSP00000415568
ENST00000489813
ENST00000470291 ENSP00000421649
ENST00000474071
ENST00000483749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000042787
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000019305
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9Y2C4
TrEMBL
UniProt Splice Variant
Entrez Gene 9941
UniGene Hs.517897
RefSeq NM_001145464 NM_005107 XM_006713442 XM_006713445 XM_006713446 XM_006713447
HUGO HGNC:3347
OMIM 604051
CCDS CCDS46795 CCDS2680
HPRD 06813
IMGT
EMBL AB020523 AB020735 AK289602 AK290107 AK301067 AK315814 BC104212 BC104213 CH471055
GenPept AAI04213 AAI04214 BAA76752 BAA76753 BAF82291 BAF82796 BAF98705 BAG62674 EAW64538
RNA Seq Atlas 9941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca