Homo sapiens Gene: PDE4A
Summary
InnateDB Gene IDBG-27301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE4A
Gene Name phosphodiesterase 4A, cAMP-specific
Synonyms DPDE2; PDE4; PDE46;
Species Homo sapiens
Ensembl Gene ENSG00000065989
Encoded Proteins
phosphodiesterase 4A, cAMP-specific
phosphodiesterase 4A, cAMP-specific
phosphodiesterase 4A, cAMP-specific
phosphodiesterase 4A, cAMP-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10416773-10469631
Strand Forward strand
Band p13.2
Transcripts
ENST00000380702 ENSP00000370078
ENST00000293683 ENSP00000293683
ENST00000344979 ENSP00000341007
ENST00000440014 ENSP00000394754
ENST00000591971 ENSP00000467137
ENST00000586275
ENST00000590407
ENST00000592685 ENSP00000468507
ENST00000589073 ENSP00000465792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 protein binding
GO:0030552 cAMP binding
GO:0046872 metal ion binding
Biological Process
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007608 sensory perception of smell
GO:0008152 metabolic process
GO:0010738 regulation of protein kinase A signaling
GO:0035690 cellular response to drug
GO:0043949 regulation of cAMP-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0032587 ruffle membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
DARPP-32 events pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.89901
RefSeq NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202 XM_005259933
HUGO
OMIM
CCDS CCDS12238 CCDS45961 CCDS45962 CCDS45963 CCDS58649
HPRD 02527
IMGT
EMBL
GenPept
RNA Seq Atlas