InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDS1

Summary

InnateDB Gene

IDBG-27938.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDS1

Gene Name

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1

Synonyms

CDS

Species

Homo sapiens

Ensembl Gene

ENSG00000163624

Encoded Proteins

IDBP-27940

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1

IDBP-476161

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:84582979-84651338

Strand

Forward strand

Band

q21.23

Transcripts

ENST00000295887	ENSP00000295887
ENST00000511298	ENSP00000421316

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004142	diacylglycerol cholinephosphotransferase activity
GO:0004605	phosphatidate cytidylyltransferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006657	CDP-choline pathway
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0007602	phototransduction
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029330

View Gene Order

ENSBTAG00000045787

Not yet available

Pathways

NETPATH

REACTOME

REACT_121000

Synthesis of PI pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

INOH

PID NCI

Cross-References

SwissProt

Q92903

TrEMBL

A0A024RDG8 D6RGC8

UniProt Splice Variant

Entrez Gene

1040

UniGene

Hs.654899 Hs.708641

RefSeq

NM_001263

HUGO

HGNC:1800

OMIM

603548

CCDS

CCDS3608

HPRD

IMGT

EMBL

AC104082 AK314245 BC074833 BC074881 CH471057 U60808 U65887

GenPept

AAC50735 AAC51184 AAH74833 AAH74881 BAG36912 EAX05950 EAX05951

RNA Seq Atlas

1040