Homo sapiens Gene: CDS1
Summary
InnateDB Gene IDBG-27938.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDS1
Gene Name CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Synonyms CDS;
Species Homo sapiens
Ensembl Gene ENSG00000163624
Encoded Proteins
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:84582979-84651338
Strand Forward strand
Band q21.23
Transcripts
ENST00000295887 ENSP00000295887
ENST00000511298 ENSP00000421316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004142 diacylglycerol cholinephosphotransferase activity
GO:0004605 phosphatidate cytidylyltransferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006657 CDP-choline pathway
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0007602 phototransduction
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PI pathway
Phospholipid metabolism pathway
Metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
Phosphatidylinositol signaling system pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RGC8
UniProt Splice Variant
Entrez Gene 1040
UniGene Hs.654899 Hs.708641
RefSeq NM_001263
HUGO HGNC:1800
OMIM 603548
CCDS CCDS3608
HPRD 11944
IMGT
EMBL AC104082
GenPept
RNA Seq Atlas 1040