Version 5.4
Homo sapiens Gene: GGT1
Summary
InnateDB Gene IDBG-2905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT1
Gene Name gamma-glutamyltransferase 1
Synonyms CD224; D22S672; D22S732; GGT; GGT 1; GTG
Species Homo sapiens
Ensembl Gene ENSG00000100031
Encoded Proteins
IDBP-2907
gamma-glutamyltransferase 1
IDBP-228357
gamma-glutamyltransferase 1
IDBP-228359
gamma-glutamyltransferase 1
IDBP-294986
gamma-glutamyltransferase 1
IDBP-294988
gamma-glutamyltransferase 1
IDBP-294989
gamma-glutamyltransferase 1
IDBP-294981
gamma-glutamyltransferase 1
IDBP-294985
gamma-glutamyltransferase 1
IDBP-367790
gamma-glutamyltransferase 1
IDBP-367796
gamma-glutamyltransferase 1
IDBP-367799
gamma-glutamyltransferase 1
IDBP-367805
gamma-glutamyltransferase 1
IDBP-367810
gamma-glutamyltransferase 1
IDBP-367855
gamma-glutamyltransferase 1
IDBP-367868
gamma-glutamyltransferase 1
IDBP-367872
gamma-glutamyltransferase 1
IDBP-367879
gamma-glutamyltransferase 1
IDBP-367881
gamma-glutamyltransferase 1
IDBP-367885
gamma-glutamyltransferase 1
IDBP-367888
gamma-glutamyltransferase 1
IDBP-367891
gamma-glutamyltransferase 1
IDBP-367895
gamma-glutamyltransferase 1
IDBP-367902
gamma-glutamyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008] The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24583750-24629005
Strand Forward strand
Band q11.23
Transcripts
ENST00000248923 ENSP00000248923
ENST00000400382 ENSP00000383232
ENST00000400380 ENSP00000383231
ENST00000401885 ENSP00000384381
ENST00000404532 ENSP00000385445
ENST00000403838 ENSP00000384820
ENST00000404223 ENSP00000385016
ENST00000404920 ENSP00000385001
ENST00000456869 ENSP00000415129
ENST00000411974 ENSP00000389935
ENST00000412658 ENSP00000393537
ENST00000445029 ENSP00000393135
ENST00000419133 ENSP00000395271
ENST00000452551 ENSP00000415553
ENST00000438643 ENSP00000403826
ENST00000412898 ENSP00000408151
ENST00000455483 ENSP00000415024
ENST00000430289 ENSP00000417044
ENST00000447416 ENSP00000400621
ENST00000432867 ENSP00000398589
ENST00000451366 ENSP00000387796
ENST00000428855 ENSP00000415068
ENST00000425895 ENSP00000387499
ENST00000474191
ENST00000487766
ENST00000466310
ENST00000490087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0006536 glutamate metabolic process
GO:0006691 leukotriene metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006751 glutathione catabolic process
GO:0006805 xenobiotic metabolic process
GO:0007283 spermatogenesis
GO:0019344 cysteine biosynthetic process
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0031638 zymogen activation
GO:0044281 small molecule metabolic process
GO:0050727 regulation of inflammatory response
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006345
View Gene Order
ENSBTAG00000046900
Not yet available
Pathways
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00460
Cyanoamino acid metabolism pathway
hsa00430
Taurine and hypotaurine metabolism pathway
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9JGF3 C9JIY6 E7ERN9 E7ETN1 E9PHP2 O75693
UniProt Splice Variant
Entrez Gene 92086
UniGene Hs.450000 Hs.645535
RefSeq NM_001282879 NM_001288833 NM_013421 NM_013430 XM_005260863 XM_005260864 XM_005261815 XM_005261817 XM_005261888 XM_005261890 XM_006723661 XM_006724365 XM_006724392 XM_006724394 XM_006724395 XM_006724396 XM_006724397 XM_006724924 XM_006724925 XM_006724926 XM_006724927 XM_006724928 XM_006724929
HUGO HGNC:4250
OMIM 137181 612338 612339 612346
CCDS CCDS42992
HPRD 01980
IMGT
EMBL AJ007493 AP000356
GenPept CAA07536
RNA Seq Atlas 102724197 2678 728441 91227 92086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca