InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM13

Summary

InnateDB Gene

IDBG-34165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM13

Gene Name

tripartite motif containing 13

Synonyms

CAR; DLEU5; LEU5; RFP2; RNF77

Species

Homo sapiens

Ensembl Gene

ENSG00000204977

Encoded Proteins

IDBP-34169

tripartite motif containing 13

IDBP-34171

tripartite motif containing 13

IDBP-34173

tripartite motif containing 13

IDBP-368546

tripartite motif containing 13

IDBP-368552

tripartite motif containing 13

IDBP-368553

tripartite motif containing 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23438823

TRIM13 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:49995888-50020481

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000356017	ENSP00000348299
ENST00000378183	ENSP00000367425
ENST00000378182	ENSP00000367424
ENST00000442421	ENSP00000404586
ENST00000420995	ENSP00000412943
ENST00000457662	ENSP00000399206
ENST00000474805
ENST00000478111

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0009653	anatomical structure morphogenesis
GO:0010332	response to gamma radiation
GO:0010942	positive regulation of cell death
GO:0016239	positive regulation of macroautophagy
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0032897	negative regulation of viral transcription
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0097038	perinuclear endoplasmic reticulum

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035235

View Gene Order

ENSBTAG00000008173

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.436922 Hs.657352 Hs.663879 Hs.681080 Hs.713391 Hs.713711

RefSeq

NM_001007278 NM_005798 NM_052811 NM_213590

HUGO

OMIM

CCDS

CCDS41888 CCDS9423

HPRD

10414

IMGT

EMBL

GenPept

RNA Seq Atlas