Homo sapiens Gene: TRIM13
Summary
InnateDB Gene IDBG-34165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM13
Gene Name tripartite motif containing 13
Synonyms CAR; DLEU5; LEU5; RFP2; RNF77;
Species Homo sapiens
Ensembl Gene ENSG00000204977
Encoded Proteins
tripartite motif containing 13
tripartite motif containing 13
tripartite motif containing 13
tripartite motif containing 13
tripartite motif containing 13
tripartite motif containing 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRIM13 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:49995888-50020481
Strand Forward strand
Band q14.2
Transcripts
ENST00000356017 ENSP00000348299
ENST00000378183 ENSP00000367425
ENST00000378182 ENSP00000367424
ENST00000442421 ENSP00000404586
ENST00000420995 ENSP00000412943
ENST00000457662 ENSP00000399206
ENST00000474805
ENST00000478111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0009653 anatomical structure morphogenesis
GO:0010332 response to gamma radiation
GO:0010942 positive regulation of cell death
GO:0016239 positive regulation of macroautophagy
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0032897 negative regulation of viral transcription
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O60858
TrEMBL A0A024RDU3 X6R9U5 X6RH27
UniProt Splice Variant
Entrez Gene 10206
UniGene Hs.436922 Hs.657352 Hs.663879 Hs.681080 Hs.713391 Hs.713711
RefSeq NM_001007278 NM_005798 NM_052811 NM_213590
HUGO HGNC:9976
OMIM 605661
CCDS CCDS41888 CCDS9423
HPRD
IMGT
EMBL AF220127 AF220128 AF241849 AF241850 AF279660 AJ224819 AK314496 AL137060 AL391993 AY191002 AY455758 AY764035 BC003579 BC063407 CH471075
GenPept AAF91315 AAG53500 AAG53501 AAH03579 AAH63407 AAK13059 AAK51624 AAO38979 AAR31110 AAV51406 BAG37096 CAA12136 CAC43391 CAH72825 CAH72826 EAX08844 EAX08845 EAX08846 EAX08847 EAX08848
RNA Seq Atlas 10206