Homo sapiens Gene: NDRG1
Summary
InnateDB Gene IDBG-36420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDRG1
Gene Name N-myc downstream regulated 1
Synonyms CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5;
Species Homo sapiens
Ensembl Gene ENSG00000104419
Encoded Proteins
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
N-myc downstream regulated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:133237171-133302022
Strand Reverse strand
Band q24.22
Transcripts
ENST00000323851 ENSP00000319977
ENST00000414097 ENSP00000404854
ENST00000521438
ENST00000521026
ENST00000521414
ENST00000519278
ENST00000517599 ENSP00000429172
ENST00000518176 ENSP00000429007
ENST00000522476 ENSP00000427894
ENST00000518066 ENSP00000431057
ENST00000523642
ENST00000522665
ENST00000517331
ENST00000522377 ENSP00000429380
ENST00000521664
ENST00000520230 ENSP00000428345
ENST00000518010
ENST00000518480 ENSP00000428802
ENST00000519228 ENSP00000429994
ENST00000519580 ENSP00000429272
ENST00000522890 ENSP00000428384
ENST00000520943 ENSP00000429840
ENST00000521544 ENSP00000429524
ENST00000517745
ENST00000518094
ENST00000522738 ENSP00000428991
ENST00000523892 ENSP00000430171
ENST00000523931
ENST00000537882 ENSP00000437443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
Experimentally validated
Total 92 [view]
Protein-Protein 87 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0017137 Rab GTPase binding
GO:0043015 gamma-tubulin binding
GO:0045296 cadherin binding
Biological Process
GO:0008219 cell death
GO:0010038 response to metal ion
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032287 peripheral nervous system myelin maintenance
GO:0045576 mast cell activation
GO:0071456 cellular response to hypoxia
GO:0090232 positive regulation of spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0015630 microtubule cytoskeleton
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Validated targets of C-MYC transcriptional repression
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372914 Hs.613170
RefSeq NM_001135242 NM_001258432 NM_001258433 NM_006096
HUGO
OMIM
CCDS CCDS34945 CCDS59112 CCDS59113
HPRD 05586
IMGT
EMBL
GenPept
RNA Seq Atlas