Homo sapiens Gene: TNNC1
Summary
InnateDB Gene IDBG-38997.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNC1
Gene Name troponin C type 1 (slow)
Synonyms CMD1Z; CMH13; TN-C; TNC; TNNC;
Species Homo sapiens
Ensembl Gene ENSG00000114854
Encoded Proteins
troponin C type 1 (slow)
troponin C type 1 (slow)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52451102-52454070
Strand Reverse strand
Band p21.1
Transcripts
ENST00000232975 ENSP00000232975
ENST00000496590 ENSP00000420596
ENST00000461086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0031013 troponin I binding
GO:0031014 troponin T binding
GO:0042803 protein homodimerization activity
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
Biological Process
GO:0002086 diaphragm contraction
GO:0006937 regulation of muscle contraction
GO:0010038 response to metal ion
GO:0030049 muscle filament sliding
GO:0032972 regulation of muscle filament sliding speed
GO:0043462 regulation of ATPase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005861 troponin complex
GO:0015629 actin cytoskeleton
GO:0043292 contractile fiber
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Muscle contraction pathway
Striated Muscle Contraction pathway
KEGG
Calcium signaling pathway pathway
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P63316
TrEMBL C9JDI3 Q6FH91
UniProt Splice Variant
Entrez Gene 7134
UniGene
RefSeq NM_003280
HUGO HGNC:11943
OMIM 191040
CCDS CCDS2857
HPRD
IMGT
EMBL AC006208 AF020769 AK313743 BC030244 CH471055 CR541865 CR541885 GU324920 M37984 X07897
GenPept AAA36772 AAB91994 AAH30244 ADL14491 BAG36483 CAA30736 CAG46663 CAG46683 EAW65226 EAW65227
RNA Seq Atlas 7134