Homo sapiens Gene: VAC14
Summary
InnateDB Gene IDBG-40481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAC14
Gene Name Vac14 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103043
Encoded Proteins
Vac14 homolog (S. cerevisiae)
Vac14 homolog (S. cerevisiae)
Vac14 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70687439-70801161
Strand Reverse strand
Band q22.2
Transcripts
ENST00000261776 ENSP00000261776
ENST00000536184 ENSP00000439284
ENST00000566655
ENST00000567648 ENSP00000463485
ENST00000564512
ENST00000566416 ENSP00000455731
ENST00000563662 ENSP00000477536
ENST00000561879
ENST00000568886 ENSP00000457809
ENST00000571759
ENST00000564685
ENST00000568548 ENSP00000454650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0016032 viral process
GO:0043550 regulation of lipid kinase activity
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0010008 endosome membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0070772 PAS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis of PIPs at the early endosome membrane pathway
Synthesis of PIPs at the late endosome membrane pathway
Synthesis of PIPs at the Golgi membrane pathway
Metabolism of lipids and lipoproteins pathway
PI Metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Synthesis of PIPs at the early endosome membrane pathway
Synthesis of PIPs at the Golgi membrane pathway
Synthesis of PIPs at the late endosome membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 55697
UniGene
RefSeq NM_018052 XM_005256041
HUGO HGNC:25507
OMIM 604632
CCDS CCDS10896
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 55697