Homo sapiens Gene: FXYD3
Summary
InnateDB Gene IDBG-43497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXYD3
Gene Name FXYD domain containing ion transport regulator 3
Synonyms MAT8; PLML;
Species Homo sapiens
Ensembl Gene ENSG00000089356
Encoded Proteins
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
FXYD domain containing ion transport regulator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35115879-35124324
Strand Forward strand
Band q13.12
Transcripts
ENST00000344013 ENSP00000339499
ENST00000346446 ENSP00000328259
ENST00000435734 ENSP00000389770
ENST00000604404 ENSP00000474438
ENST00000603181 ENSP00000474851
ENST00000604255 ENSP00000473929
ENST00000604504
ENST00000603449 ENSP00000474055
ENST00000605550 ENSP00000474514
ENST00000604804 ENSP00000475056
ENST00000605552 ENSP00000474855
ENST00000603524 ENSP00000474223
ENST00000604621 ENSP00000474526
ENST00000605677 ENSP00000474622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0050790 regulation of catalytic activity
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q14802
TrEMBL
UniProt Splice Variant
Entrez Gene 5349
UniGene
RefSeq NM_021910 XM_005258992 NM_001136007 NM_001136008 NM_001136009 NM_001136010 NM_001136011 NM_001136012 NM_005971 XM_005258995 XM_006723242
HUGO HGNC:4027
OMIM 604996
CCDS CCDS12443 CCDS12442 CCDS46048 CCDS46049 CCDS46050
HPRD 05410
IMGT
EMBL AC020907 BC005238 BC090044 BT006712 BU157560 CR456945 CR542197 U28249 X93036
GenPept AAA73922 AAH05238 AAH90044 AAP35358 CAA63604 CAG33226 CAG46994
RNA Seq Atlas 5349