Homo sapiens Gene: ING2
Summary
InnateDB Gene IDBG-46020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ING2
Gene Name inhibitor of growth family, member 2
Synonyms ING1L; p33ING2;
Species Homo sapiens
Ensembl Gene ENSG00000168556
Encoded Proteins
inhibitor of growth family, member 2
inhibitor of growth family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:183504994-183511096
Strand Forward strand
Band q35.1
Transcripts
ENST00000302327 ENSP00000307183
ENST00000412117 ENSP00000410291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0032403 protein complex binding
GO:0035064 methylated histone binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007141 male meiosis I
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008285 negative regulation of cell proliferation
GO:0016568 chromatin modification
GO:0030317 sperm motility
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0040008 regulation of growth
GO:0043065 positive regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048133 male germ-line stem cell division
GO:0072520 seminiferous tubule development
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000772 regulation of cellular senescence
GO:2001020 regulation of response to DNA damage stimulus
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016580 Sin3 complex
GO:0016602 CCAAT-binding factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J4X5
UniProt Splice Variant
Entrez Gene 3622
UniGene Hs.107153
RefSeq NM_001564
HUGO HGNC:6063
OMIM 604215
CCDS CCDS3833
HPRD 05021
IMGT
EMBL AC107214
GenPept
RNA Seq Atlas 3622