InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ING2

Summary

InnateDB Gene

IDBG-46020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ING2

Gene Name

inhibitor of growth family, member 2

Synonyms

ING1L; p33ING2

Species

Homo sapiens

Ensembl Gene

ENSG00000168556

Encoded Proteins

IDBP-46022

inhibitor of growth family, member 2

IDBP-380042

inhibitor of growth family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:183504994-183511096

Strand

Forward strand

Band

q35.1

Transcripts

ENST00000302327	ENSP00000307183
ENST00000412117	ENSP00000410291

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032403	protein complex binding
GO:0035064	methylated histone binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007141	male meiosis I
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0030317	sperm motility
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048133	male germ-line stem cell division
GO:0072520	seminiferous tubule development
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000772	regulation of cellular senescence
GO:2001020	regulation of response to DNA damage stimulus
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0016580	Sin3 complex
GO:0016602	CCAAT-binding factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000063049

View Gene Order

ENSBTAG00000047706

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9H160

TrEMBL

C9J4X5

UniProt Splice Variant

Entrez Gene

3622

UniGene

Hs.107153

RefSeq

NM_001564

HUGO

HGNC:6063

OMIM

604215

CCDS

CCDS3833

HPRD

IMGT

EMBL

AB012853 AB196793 AC107214 AF053537 AF062747 AF062748 AJ006851 AK294310 BC030128

GenPept

AAG11395 AAG11396 AAH30128 BAA36419 BAF30476 BAH11731 CAC20567

RNA Seq Atlas

3622