Homo sapiens Gene: IL17C
Summary
InnateDB Gene IDBG-46304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17C
Gene Name interleukin 17C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124391
Encoded Proteins
interleukin 17C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL17C is an essential autocrine cytokine that regulates innate epithelial immune responses.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Il17c is an essential autocrine cytokine that regulates innate epithelial immune responses. (Demonstrated in human)
[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.
Entrez Gene
Summary The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:88638591-88640473
Strand Forward strand
Band q24.2
Transcripts
ENST00000244241 ENSP00000244241
ENST00000569133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0030223 neutrophil differentiation
GO:0045087 innate immune response (InnateDB)
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.278911
RefSeq NM_013278
HUGO
OMIM
CCDS CCDS42217
HPRD 06863
IMGT
EMBL
GenPept
RNA Seq Atlas