|Homo sapiens Gene: IL17C|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 17C|
|Useful resources||Stemformatics EHFPI ImmGen|
IL17C is an essential autocrine cytokine that regulates innate epithelial immune responses.
|InnateDB Annotation from Orthologs|
[Mus musculus] Il17c is an essential autocrine cytokine that regulates innate epithelial immune responses. (Demonstrated in human)
[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 16:88638591-88640473|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RNA Seq Atlas|