Version 5.4
Homo sapiens Gene: IL17C
Summary
InnateDB Gene IDBG-46304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17C
Gene Name interleukin 17C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124391
Encoded Proteins
IDBP-46306
interleukin 17C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21993848
IL17C is an essential autocrine cytokine that regulates innate epithelial immune responses.
InnateDB Annotation from Orthologs
Summary
PMID 21993848
[Mus musculus] Il17c is an essential autocrine cytokine that regulates innate epithelial immune responses. (Demonstrated in human)
PMID 24412611
[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.
Entrez Gene
Summary The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:88638591-88640473
Strand Forward strand
Band q24.2
Transcripts
ENST00000244241 ENSP00000244241
ENST00000569133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0030223 neutrophil differentiation
GO:0045087 innate immune response (InnateDB)
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046108
View Gene Order
ENSBTAG00000047128
Not yet available
Cross-References
SwissProt Q9P0M4
TrEMBL
UniProt Splice Variant
Entrez Gene 27189
UniGene Hs.278911
RefSeq NM_013278
HUGO HGNC:5983
OMIM 604628
CCDS CCDS42217
HPRD
IMGT
EMBL AF142410 AF152099 AY358471 BC069152 BC101835 BC112196
GenPept AAF28105 AAG27921 AAH69152 AAI01836 AAI12197 AAQ88835
RNA Seq Atlas 27189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca