Version 5.4
Homo sapiens Gene: ACE2
Summary
InnateDB Gene IDBG-46534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACE2
Gene Name angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130234
Encoded Proteins
IDBP-46538
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
IDBP-362748
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22837003
ACE2 deficiency results in increased susceptibility to intestinal inflammation induced by epithelial damage. ACE2 links amino acid malnutrition to altered gut microbiota, which leads to colitis susceptibility. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22837003
[Mus musculus] Ace2 deficiency results in increased susceptibility to intestinal inflammation induced by epithelial damage. Ace2 links amino acid malnutrition to altered gut microbiota, which leads to colitis susceptibility.
Entrez Gene
Summary The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:15561033-15602148
Strand Reverse strand
Band p22.2
Transcripts
ENST00000252519 ENSP00000252519
ENST00000427411 ENSP00000389326
ENST00000471548
ENST00000473851
ENST00000484756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0001948 glycoprotein binding
GO:0004175 endopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0008270 zinc ion binding
GO:0017046 peptide hormone binding
GO:0042277 peptide binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0002003 angiotensin maturation
GO:0002005 angiotensin catabolic process in blood
GO:0003051 angiotensin-mediated drinking behavior
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006508 proteolysis
GO:0009615 response to virus
GO:0019229 regulation of vasoconstriction
GO:0032800 receptor biosynthetic process
GO:0042127 regulation of cell proliferation
GO:0042312 regulation of vasodilation
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0050727 regulation of inflammatory response
GO:0060135 maternal process involved in female pregnancy
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015405
View Gene Order
ENSBTAG00000034402
Not yet available
Pathways
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.178098 Hs.599579
RefSeq NM_021804
HUGO
OMIM
CCDS CCDS14169
HPRD 02274
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca