Homo sapiens Gene: U2AF1
Summary
InnateDB Gene IDBG-4654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol U2AF1
Gene Name U2 small nuclear RNA auxiliary factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160201
Encoded Proteins
U2 small nuclear RNA auxiliary factor 1
U2 small nuclear RNA auxiliary factor 1
U2 small nuclear RNA auxiliary factor 1
U2 small nuclear RNA auxiliary factor 1
U2 small nuclear RNA auxiliary factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:43092956-43107587
Strand Reverse strand
Band q22.3
Transcripts
ENST00000380276 ENSP00000369629
ENST00000291552 ENSP00000291552
ENST00000398137 ENSP00000381205
ENST00000464750 ENSP00000420672
ENST00000459639 ENSP00000418705
ENST00000475639
ENST00000478282
ENST00000471250
ENST00000486519
ENST00000463599
ENST00000496462
ENST00000468039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 139 [view]
Protein-Protein 138 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
mRNA 3'-end processing pathway
RNA Polymerase II Transcription Termination pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
Shigellosis pathway
INOH
PID BIOCARTA
Spliceosomal assembly [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597777 Hs.629181 Hs.687214 Hs.738829
RefSeq NM_001025203 NM_001025204 NM_006758 XM_006723927 XM_006723928 XM_006723929 XM_006726798 XM_006726799 XM_006726800
HUGO
OMIM
CCDS CCDS13694 CCDS33574 CCDS42948
HPRD 01871
IMGT
EMBL
GenPept
RNA Seq Atlas