Version 5.4
Mus musculus Gene: Tmem27
Summary
InnateDB Gene IDBG-184488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem27
Gene Name transmembrane protein 27
Synonyms 0610008J07Rik; NX-17; NX17
Species Mus musculus
Ensembl Gene ENSMUSG00000015401
Encoded Proteins
IDBP-184490
transmembrane protein 27
IDBP-256340
transmembrane protein 27
IDBP-542756
transmembrane protein 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147003:
This gene encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:164088830-164118860
Strand Forward strand
Band F5
Transcripts
ENSMUST00000015545 ENSMUSP00000015545
ENSMUST00000112280 ENSMUSP00000107899
ENSMUST00000141818 ENSMUSP00000123629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0035543 positive regulation of SNARE complex assembly
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0051957 positive regulation of amino acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147003
View Gene Order
ENSBTAG00000048296
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.143766 Mm.420896
RefSeq NM_020626 XM_006528923
OMIM
CCDS CCDS30517
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca