Version 5.4
| Homo sapiens Gene: ABCB8 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-48655.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ABCB8 | ||||||||||||||||||
| Gene Name | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | ||||||||||||||||||
| Synonyms | EST328128; M-ABC1; MABC1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000197150 | ||||||||||||||||||
| Encoded Proteins |
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008] This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 7:151028422-151047782 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q36.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Mitochondrial ABC transporters pathway
ABC-family proteins mediated transport pathway
Transmembrane transport of small molecules pathway
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| KEGG |
ABC transporters pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.647118 Hs.649700 Hs.735539 | ||||||||||||||||||
| RefSeq | NM_001282291 NM_001282292 NM_001282293 NM_007188 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS5913 CCDS64798 CCDS64799 CCDS64800 | ||||||||||||||||||
| HPRD | 10400 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||