Homo sapiens Gene: FGF1
Summary
InnateDB Gene IDBG-51235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF1
Gene Name fibroblast growth factor 1 (acidic)
Synonyms AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1;
Species Homo sapiens
Ensembl Gene ENSG00000113578
Encoded Proteins
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
fibroblast growth factor 1 (acidic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142592178-142698070
Strand Reverse strand
Band q31.3
Transcripts
ENST00000378046 ENSP00000367285
ENST00000337706 ENSP00000338548
ENST00000360966 ENSP00000354231
ENST00000359370 ENSP00000352329
ENST00000394496 ENSP00000378005
ENST00000407758 ENSP00000383969
ENST00000419524 ENSP00000396195
ENST00000441680 ENSP00000404742
ENST00000411960 ENSP00000399458
ENST00000489937
ENST00000494344
ENST00000494579
ENST00000621536 ENSP00000480791
ENST00000619447 ENSP00000480980
ENST00000610990 ENSP00000481868
ENST00000612258 ENSP00000479024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0030544 Hsp70 protein binding
GO:0044548 S100 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001759 organ induction
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0034605 cellular response to heat
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060681 branch elongation involved in ureteric bud branching
GO:0072163 mesonephric epithelium development
GO:1902533 positive regulation of intracellular signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR3 mutants pathway
Signaling by FGFR mutants pathway
Activated point mutants of FGFR2 pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
FRS2-mediated cascade pathway
Phospholipase C-mediated cascade pathway
FGFR2b ligand binding and activation pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
FGFR2c ligand binding and activation pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by FGFR1 mutants pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
PI3K Cascade pathway
FGFR1c ligand binding and activation pathway
IRS-mediated signalling pathway
FGFR1b ligand binding and activation pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
FGFR3b ligand binding and activation pathway
FGFR3 ligand binding and activation pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
FGFR3c ligand binding and activation pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Negative regulation of FGFR signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Signaling by activated point mutants of FGFR3 pathway
Signaling by activated point mutants of FGFR1 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
FGFR4 ligand binding and activation pathway
FGFR1 ligand binding and activation pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Melanoma pathway
INOH
GPCR signaling pathway
FGF signaling pathway pathway
PID BIOCARTA
PID NCI
FGF signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137 XM_005268390 XM_006714762
HUGO
OMIM
CCDS CCDS4275 CCDS4276
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas