Homo sapiens Gene: TXNRD1
Summary
InnateDB Gene IDBG-54357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNRD1
Gene Name thioredoxin reductase 1
Synonyms GRIM-12; TR; TR1; TRXR1; TXNR;
Species Homo sapiens
Ensembl Gene ENSG00000198431
Encoded Proteins
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
thioredoxin reductase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3\' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:104215779-104350305
Strand Forward strand
Band q23.3
Transcripts
ENST00000354940 ENSP00000347020
ENST00000388854 ENSP00000373506
ENST00000397736 ENSP00000380844
ENST00000429002 ENSP00000412045
ENST00000503506 ENSP00000421934
ENST00000525566 ENSP00000434516
ENST00000534282
ENST00000526006
ENST00000526266 ENSP00000431294
ENST00000526691 ENSP00000435929
ENST00000531691 ENSP00000431925
ENST00000526390 ENSP00000435123
ENST00000531689 ENSP00000433507
ENST00000529546 ENSP00000434919
ENST00000529751 ENSP00000432273
ENST00000526207
ENST00000528079 ENSP00000433732
ENST00000526580 ENSP00000433887
ENST00000529784 ENSP00000436229
ENST00000524698 ENSP00000433425
ENST00000527688 ENSP00000433935
ENST00000527335 ENSP00000433599
ENST00000526950 ENSP00000432812
ENST00000525265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0001707 mesoderm formation
GO:0007165 signal transduction
GO:0007369 gastrulation
GO:0008033 tRNA processing
GO:0008283 cell proliferation
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045454 cell redox homeostasis
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Cellular responses to stress pathway
Metabolism of lipids and lipoproteins pathway
Detoxification of Reactive Oxygen Species pathway
Synthesis and interconversion of nucleotide di- and triphosphates pathway
PPARA activates gene expression pathway
Metabolism of nucleotides pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Pyrimidine metabolism pathway
Selenocompound metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654922 Hs.728817 Hs.741567
RefSeq NM_001093771 NM_001261445 NM_001261446 NM_003330 NM_182729 NM_182742 NM_182743
HUGO
OMIM
CCDS CCDS53820 CCDS53821 CCDS53823 CCDS58274
HPRD 03068
IMGT
EMBL
GenPept
RNA Seq Atlas