Version 5.4
Homo sapiens Gene: SLU7
Summary
InnateDB Gene IDBG-56099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLU7
Gene Name SLU7 splicing factor homolog (S. cerevisiae)
Synonyms 9G8; hSlu7
Species Homo sapiens
Ensembl Gene ENSG00000164609
Encoded Proteins
IDBP-56101
SLU7 splicing factor homolog (S. cerevisiae)
IDBP-481585
SLU7 splicing factor homolog (S. cerevisiae)
IDBP-476200
SLU7 splicing factor homolog (S. cerevisiae)
IDBP-475969
SLU7 splicing factor homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:160401641-160421711
Strand Reverse strand
Band q33.3
Transcripts
ENST00000297151 ENSP00000297151
ENST00000521320
ENST00000520841
ENST00000523219
ENST00000521826 ENSP00000428943
ENST00000521190
ENST00000519349 ENSP00000429990
ENST00000518268
ENST00000520664 ENSP00000428362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000386 second spliceosomal transesterification activity
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030628 pre-mRNA 3'-splice site binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006886 intracellular protein transport
GO:0034605 cellular response to heat
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020409
View Gene Order
ENSBTAG00000008457
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt O95391
TrEMBL E5RGM7 E5RK41
UniProt Splice Variant
Entrez Gene 10569
UniGene Hs.435342 Hs.653742
RefSeq NM_006425
HUGO HGNC:16939
OMIM 605974
CCDS CCDS4352
HPRD
IMGT
EMBL AC091842 AF101074 AY486334 BC010634 CH471062 DQ174516 DQ174517
GenPept AAD13774 AAH10634 AAS59410 ABA08382 ABA08383 EAW61554 EAW61555
RNA Seq Atlas 10569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca