Version 5.4
Homo sapiens Gene: ATP2C1
Summary
InnateDB Gene IDBG-56432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP2C1
Gene Name ATPase, Ca++ transporting, type 2C, member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000017260
Encoded Proteins
IDBP-56434
ATPase, Ca++ transporting, type 2C, member 1
IDBP-56438
ATPase, Ca++ transporting, type 2C, member 1
IDBP-384038
ATPase, Ca++ transporting, type 2C, member 1
IDBP-384039
ATPase, Ca++ transporting, type 2C, member 1
IDBP-485000
ATPase, Ca++ transporting, type 2C, member 1
IDBP-484308
ATPase, Ca++ transporting, type 2C, member 1
IDBP-485361
ATPase, Ca++ transporting, type 2C, member 1
IDBP-474016
ATPase, Ca++ transporting, type 2C, member 1
IDBP-478557
ATPase, Ca++ transporting, type 2C, member 1
IDBP-473702
ATPase, Ca++ transporting, type 2C, member 1
IDBP-481269
ATPase, Ca++ transporting, type 2C, member 1
IDBP-474528
ATPase, Ca++ transporting, type 2C, member 1
IDBP-485360
ATPase, Ca++ transporting, type 2C, member 1
IDBP-485039
ATPase, Ca++ transporting, type 2C, member 1
IDBP-479179
ATPase, Ca++ transporting, type 2C, member 1
IDBP-485100
ATPase, Ca++ transporting, type 2C, member 1
IDBP-477196
ATPase, Ca++ transporting, type 2C, member 1
IDBP-475583
ATPase, Ca++ transporting, type 2C, member 1
IDBP-485358
ATPase, Ca++ transporting, type 2C, member 1
IDBP-601382
ATPase, Ca++ transporting, type 2C, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:130850595-131016712
Strand Forward strand
Band q22.1
Transcripts
ENST00000328560 ENSP00000329664
ENST00000359644 ENSP00000352665
ENST00000422190 ENSP00000402677
ENST00000428331 ENSP00000395809
ENST00000504381 ENSP00000425320
ENST00000505330 ENSP00000423774
ENST00000507488 ENSP00000421326
ENST00000510168 ENSP00000427461
ENST00000508532 ENSP00000424783
ENST00000513801 ENSP00000422872
ENST00000504948 ENSP00000423330
ENST00000505072 ENSP00000427625
ENST00000509662 ENSP00000426849
ENST00000508297 ENSP00000421261
ENST00000504612 ENSP00000425228
ENST00000513636
ENST00000515854 ENSP00000422890
ENST00000514654
ENST00000504571 ENSP00000422489
ENST00000508660 ENSP00000424930
ENST00000510774
ENST00000507194 ENSP00000427087
ENST00000533801 ENSP00000432956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004871 signal transducer activity
GO:0005388 calcium-transporting ATPase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0015410 manganese-transporting ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0008544 epidermis development
GO:0016339 calcium-dependent cell-cell adhesion
GO:0030026 cellular manganese ion homeostasis
GO:0031532 actin cytoskeleton reorganization
GO:0032468 Golgi calcium ion homeostasis
GO:0032472 Golgi calcium ion transport
GO:0034220 ion transmembrane transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032570
View Gene Order
ENSBTAG00000011626
Not yet available
Pathways
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.584884 Hs.713021
RefSeq NM_001001485 NM_001001486 NM_001001487 NM_001199179 NM_001199180 NM_001199181 NM_001199182 NM_001199183 NM_001199184 NM_001199185 NM_014382 XM_005247354 XM_005247355 XM_005247356 XM_005247357 XM_005247358 XM_006713585
HUGO
OMIM
CCDS CCDS33856 CCDS46912 CCDS46913 CCDS46914 CCDS56278 CCDS56279 CCDS56280 CCDS56281 CCDS75006
HPRD 05089
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca