InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GRB10

Summary

InnateDB Gene

IDBG-628761.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRB10

Gene Name

growth factor receptor-bound protein 10

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017086

Encoded Proteins

IDBP-680147

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106070:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:5104899-5244348

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022720

ENSBTAP00000022720

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0042326	negative regulation of phosphorylation
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048009	insulin-like growth factor receptor signaling pathway