Bos taurus Gene: GRB10
Summary
InnateDB Gene IDBG-628761.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB10
Gene Name growth factor receptor-bound protein 10
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017086
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106070:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:5104899-5244348
Strand Forward strand
Band
Transcripts
ENSBTAT00000022720 ENSBTAP00000022720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0042326 negative regulation of phosphorylation
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
REACTOME
SHC-related events pathway
SHC activation pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IRS activation pathway
Signal attenuation pathway
Signaling by Insulin receptor pathway
SHC activation pathway
SHC-related events pathway
Signaling by Insulin receptor pathway
Signaling by SCF-KIT pathway
Signal attenuation pathway
Insulin receptor signalling cascade pathway
IRS activation pathway
IRS-related events pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
IGF1 pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
PDGFR-beta signaling pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.24356
RefSeq NM_001192586 XM_005205091 XM_005205092 XM_005205093
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas