Homo sapiens Gene: LIPT1
Summary
InnateDB Gene IDBG-63192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIPT1
Gene Name lipoyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144182
Encoded Proteins
lipoyltransferase 1
lipoyltransferase 1
lipoyltransferase 1
lipoyltransferase 1
lipoyltransferase 1
lipoyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:99154955-99163157
Strand Forward strand
Band q11.2
Transcripts
ENST00000393473 ENSP00000377115
ENST00000393471 ENSP00000377114
ENST00000449211 ENSP00000387387
ENST00000434566 ENSP00000393591
ENST00000415142 ENSP00000398168
ENST00000436234 ENSP00000406314
ENST00000480170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006464 cellular protein modification process
GO:0006629 lipid metabolic process
GO:0009249 protein lipoylation
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lipoic acid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.685390 Hs.719172 Hs.739177
RefSeq NM_001204830 NM_015929 NM_145197 NM_145198 NM_145199
HUGO
OMIM
CCDS CCDS2039
HPRD 17282
IMGT
EMBL
GenPept
RNA Seq Atlas