Homo sapiens Gene: GADD45A
Summary
InnateDB Gene IDBG-99580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GADD45A
Gene Name growth arrest and DNA-damage-inducible, alpha
Synonyms DDIT1; GADD45;
Species Homo sapiens
Ensembl Gene ENSG00000116717
Encoded Proteins
growth arrest and DNA-damage-inducible, alpha
growth arrest and DNA-damage-inducible, alpha
growth arrest and DNA-damage-inducible, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:67685061-67688338
Strand Forward strand
Band p31.3
Transcripts
ENST00000370986 ENSP00000360025
ENST00000370985 ENSP00000360024
ENST00000460575
ENST00000484245
ENST00000617962 ENSP00000482814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 139 [view]
Protein-Protein 127 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0005515 protein binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000185 activation of MAPKKK activity
GO:0006281 DNA repair
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0007098 centrosome cycle
GO:0042770 signal transduction in response to DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:0071260 cellular response to mechanical stimulus
GO:0071479 cellular response to ionizing radiation
GO:1900745 positive regulation of p38MAPK cascade
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
Cell cycle pathway
p53 signaling pathway pathway
INOH
PID BIOCARTA
Atm signaling pathway [Biocarta view]
Cell cycle: g2/m checkpoint [Biocarta view]
Hypoxia and p53 in the cardiovascular system [Biocarta view]
P53 signaling pathway [Biocarta view]
PID NCI
Aurora A signaling
Direct p53 effectors
ATF-2 transcription factor network
Validated targets of C-MYC transcriptional repression
FoxO family signaling
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.80409
RefSeq NM_001199741 NM_001199742 NM_001924
HUGO
OMIM
CCDS CCDS55605 CCDS640 CCDS72806
HPRD 00528
IMGT
EMBL
GenPept
RNA Seq Atlas