InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GADD45A

Summary

InnateDB Gene

IDBG-99580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45A

Gene Name

growth arrest and DNA-damage-inducible, alpha

Synonyms

DDIT1; GADD45

Species

Homo sapiens

Ensembl Gene

ENSG00000116717

Encoded Proteins

IDBP-99582

growth arrest and DNA-damage-inducible, alpha

IDBP-99584

growth arrest and DNA-damage-inducible, alpha

IDBP-809276

growth arrest and DNA-damage-inducible, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:67685061-67688338

Strand

Forward strand

Band

p31.3

Transcripts

ENST00000370986	ENSP00000360025
ENST00000370985	ENSP00000360024
ENST00000460575
ENST00000484245
ENST00000617962	ENSP00000482814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	139 [view]
Protein-Protein	127 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0005515	protein binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000185	activation of MAPKKK activity
GO:0006281	DNA repair
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0007098	centrosome cycle
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0071260	cellular response to mechanical stimulus
GO:0071479	cellular response to ionizing radiation
GO:1900745	positive regulation of p38MAPK cascade
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036390

View Gene Order

ENSBTAG00000013860

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04110

Cell cycle pathway

hsa04010

MAPK signaling pathway pathway

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

aurora_a_pathway

Aurora A signaling

p53downstreampathway

Direct p53 effectors

atf2_pathway

ATF-2 transcription factor network

myc_represspathway

Validated targets of C-MYC transcriptional repression

foxopathway

FoxO family signaling

tap63pathway

Validated transcriptional targets of TAp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.80409

RefSeq

NM_001199741 NM_001199742 NM_001924

HUGO

OMIM

CCDS

CCDS55605 CCDS640 CCDS72806

HPRD

00528

IMGT

EMBL

GenPept

RNA Seq Atlas