Version 5.4
Bos taurus Gene: KDM4A
Summary
InnateDB Gene IDBG-640369.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM4A
Gene Name lysine-specific demethylase 4A
Synonyms JMJD2A
Species Bos taurus
Ensembl Gene ENSBTAG00000002078
Encoded Proteins
IDBP-692674
lysine (K)-specific demethylase 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24656046
[Mus musculus] The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066135:
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:102926388-102963687
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002687 ENSBTAP00000002687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0035064 methylated histone binding
GO:0046872 metal ion binding
GO:0051864 histone demethylase activity (H3-K36 specific)
Biological Process
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016577 histone demethylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070544 histone H3-K36 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000066135
View Gene Order
ENSMUSG00000033326
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_218274
Chromatin organization pathway
REACT_256030
HDMs demethylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BPL5
UniProt Splice Variant
Entrez Gene 512622
UniGene Bt.58925
RefSeq NM_001206316 XM_005204710 XM_005204711
HUGO HGNC:22978
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009042
GenPept
RNA Seq Atlas 512622

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca