Homo sapiens Gene: KDM4A
Summary
InnateDB Gene IDBG-97512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM4A
Gene Name lysine (K)-specific demethylase 4A
Synonyms JHDM3A; JMJD2; JMJD2A; TDRD14A;
Species Homo sapiens
Ensembl Gene ENSG00000066135
Encoded Proteins
lysine (K)-specific demethylase 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
Entrez Gene
Summary This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43650158-43705515
Strand Forward strand
Band p34.2
Transcripts
ENST00000372396 ENSP00000361473
ENST00000463151
ENST00000485249
ENST00000472265
ENST00000481296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 28 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0035064 methylated histone binding
GO:0051864 histone demethylase activity (H3-K36 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016032 viral process
GO:0016577 histone demethylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
GO:0070544 histone H3-K36 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HDMs demethylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.155983 Hs.607166 Hs.620827
RefSeq NM_014663 XM_005271354 XM_005271355 XM_005271356
HUGO
OMIM
CCDS CCDS491
HPRD 17168
IMGT
EMBL
GenPept
RNA Seq Atlas