InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SCNN1A

Summary

InnateDB Gene

IDBG-640505.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCNN1A

Gene Name

amiloride-sensitive sodium channel subunit alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002631

Encoded Proteins

IDBP-692777

amiloride-sensitive sodium channel subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111319:
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104364800-104396610

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003413

ENSBTAP00000003413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0050699	WW domain binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0050891	multicellular organismal water homeostasis
GO:0055078	sodium ion homeostasis

Cellular Component

GO:0005829	cytosol
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031514	motile cilium
GO:0034706	sodium channel complex
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome