Version 5.4
Bos taurus Gene: S1PR2
Summary
InnateDB Gene IDBG-643243.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S1PR2
Gene Name sphingosine 1-phosphate receptor 2
Synonyms EDG5
Species Bos taurus
Ensembl Gene ENSBTAG00000002738
Encoded Proteins
IDBP-695786
sphingosine 1-phosphate receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000267534:
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:15974816-15982578
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003550 ENSBTAP00000003550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005178 integrin binding
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0090394 negative regulation of excitatory postsynaptic membrane potential
GO:1903142 positive regulation of establishment of endothelial barrier
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000043895
View Gene Order
ENSG00000267534
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_232027
Lysosphingolipid and LPA receptors pathway
REACT_188257
Signal Transduction pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_18365
Lysosphingolipid and LPA receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
s1p_meta_pathway
Sphingosine 1-phosphate (S1P) pathway
s1p_s1p2_pathway
S1P2 pathway
Cross-References
SwissProt
TrEMBL A2VDV6
UniProt Splice Variant
Entrez Gene 540305
UniGene Bt.7519
RefSeq NM_001081541
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133422 DAAA02019451
GenPept AAI33423
RNA Seq Atlas 540305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca