InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARPC4

Summary

InnateDB Gene

IDBG-644712.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPC4

Gene Name

Actin-related protein 2/3 complex subunit 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007964

Encoded Proteins

IDBP-697369

Actin-related protein 2/3 complex subunit 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241553:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:16958695-16967839

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010469

ENSBTAP00000010469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030674	protein binding, bridging

Biological Process

GO:0030041	actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0015629	actin cytoskeleton
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome