Homo sapiens Gene: NCK2
Summary
InnateDB Gene IDBG-64634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCK2
Gene Name NCK adaptor protein 2
Synonyms GRB4; NCKbeta;
Species Homo sapiens
Ensembl Gene ENSG00000071051
Encoded Proteins
NCK adaptor protein 2
NCK adaptor protein 2
NCK adaptor protein 2
NCK adaptor protein 2
NCK adaptor protein 2
NCK adaptor protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:105744897-105894274
Strand Forward strand
Band q12.2
Transcripts
ENST00000233154 ENSP00000233154
ENST00000393349 ENSP00000377018
ENST00000393348 ENSP00000377017
ENST00000451463 ENSP00000410428
ENST00000425756 ENSP00000408040
ENST00000522586 ENSP00000431109
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0030159 receptor signaling complex scaffold activity
Biological Process
GO:0006417 regulation of translation
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007411 axon guidance
GO:0008285 negative regulation of cell proliferation
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030838 positive regulation of actin filament polymerization
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0012506 vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
Developmental Biology pathway
Cell-Cell communication pathway
Nephrin interactions pathway
Signaling by VEGF pathway
Axon guidance pathway
Activation of Rac pathway
Signal Transduction pathway
Downstream signal transduction pathway
Ephrin signaling pathway
VEGFA-VEGFR2 Pathway pathway
EPH-Ephrin signaling pathway
Signaling by Robo receptor pathway
Signaling by PDGF pathway
KEGG
ErbB signaling pathway pathway
Axon guidance pathway
T cell receptor signaling pathway pathway
Pathogenic Escherichia coli infection pathway
INOH
PID BIOCARTA
PID NCI
Reelin signaling pathway
IGF1 pathway
Integrin-linked kinase signaling
Ephrin B reverse signaling
Insulin Pathway
Cross-References
SwissProt
TrEMBL E7ERP6 Q53T91
UniProt Splice Variant
Entrez Gene 8440
UniGene Hs.529244 Hs.707062
RefSeq NM_003581 NM_001004720 NM_001004722 XM_006712797 XM_006712798
HUGO HGNC:7665
OMIM 604930
CCDS CCDS33266
HPRD 05378
IMGT
EMBL AC009505 AC010978
GenPept AAY14937
RNA Seq Atlas 8440