Homo sapiens Gene: EPS8L1
Summary
InnateDB Gene IDBG-70003.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPS8L1
Gene Name EPS8-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131037
Encoded Proteins
EPS8-like 1
EPS8-like 1
EPS8-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55072020-55087923
Strand Forward strand
Band q13.42
Transcripts
ENST00000201647 ENSP00000201647
ENST00000245618 ENSP00000245618
ENST00000540810 ENSP00000437541
ENST00000585347
ENST00000588359 ENSP00000466245
ENST00000586329 ENSP00000466828
ENST00000587715
ENST00000587786 ENSP00000465830
ENST00000592044
ENST00000592102
ENST00000589362
ENST00000590232
ENST00000592824
ENST00000590610
ENST00000592284
ENST00000592318
ENST00000589694
ENST00000591219
ENST00000587901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0042608 T cell receptor binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0016310 phosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438862
RefSeq NM_017729 NM_133180
HUGO
OMIM
CCDS CCDS12914 CCDS12915
HPRD 13276
IMGT
EMBL
GenPept
RNA Seq Atlas