Homo sapiens Gene: GDA
Summary
InnateDB Gene IDBG-70608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDA
Gene Name guanine deaminase
Synonyms CYPIN; GUANASE; NEDASIN;
Species Homo sapiens
Ensembl Gene ENSG00000119125
Encoded Proteins
guanine deaminase
guanine deaminase
guanine deaminase
guanine deaminase
guanine deaminase
guanine deaminase
guanine deaminase
guanine deaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:72114595-72257193
Strand Forward strand
Band q21.13
Transcripts
ENST00000358399 ENSP00000351170
ENST00000376986 ENSP00000366185
ENST00000238018 ENSP00000238018
ENST00000414671 ENSP00000403897
ENST00000436438 ENSP00000400857
ENST00000475764 ENSP00000436619
ENST00000477618
ENST00000489618 ENSP00000434682
ENST00000545168 ENSP00000437972
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008892 guanine deaminase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006147 guanine catabolic process
GO:0006195 purine nucleotide catabolic process
GO:0007399 nervous system development
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Purine metabolism pathway
Purine catabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q5SZC3
UniProt Splice Variant
Entrez Gene 9615
UniGene Hs.494163 Hs.700124
RefSeq NM_001242505 NM_001242506 NM_001242507 NM_004293 XM_005252317 XM_006717326
HUGO HGNC:4212
OMIM 139260
CCDS CCDS56576 CCDS56577 CCDS6641
HPRD 08849
IMGT
EMBL AL135924 AL583829 AL590311
GenPept
RNA Seq Atlas 9615