Version 5.4
Homo sapiens Gene: ZEB2
Summary
InnateDB Gene IDBG-71713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZEB2
Gene Name zinc finger E-box binding homeobox 2
Synonyms HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B
Species Homo sapiens
Ensembl Gene ENSG00000169554
Encoded Proteins
IDBP-71715
zinc finger E-box binding homeobox 2
IDBP-244789
zinc finger E-box binding homeobox 2
IDBP-294094
zinc finger E-box binding homeobox 2
IDBP-294107
zinc finger E-box binding homeobox 2
IDBP-386304
zinc finger E-box binding homeobox 2
IDBP-386307
zinc finger E-box binding homeobox 2
IDBP-813702
zinc finger E-box binding homeobox 2
IDBP-813708
zinc finger E-box binding homeobox 2
IDBP-386316
zinc finger E-box binding homeobox 2
IDBP-386318
zinc finger E-box binding homeobox 2
IDBP-813705
zinc finger E-box binding homeobox 2
IDBP-813704
zinc finger E-box binding homeobox 2
IDBP-813706
zinc finger E-box binding homeobox 2
IDBP-584141
zinc finger E-box binding homeobox 2
IDBP-599457
zinc finger E-box binding homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:144388001-144524580
Strand Reverse strand
Band q22.3
Transcripts
ENST00000303660 ENSP00000302501
ENST00000392861 ENSP00000376601
ENST00000409487 ENSP00000386854
ENST00000409211 ENSP00000387256
ENST00000419938 ENSP00000394777
ENST00000427902 ENSP00000395496
ENST00000431672 ENSP00000475267
ENST00000440875 ENSP00000475553
ENST00000434448
ENST00000453352
ENST00000435831 ENSP00000400993
ENST00000444559 ENSP00000399451
ENST00000497268
ENST00000472146
ENST00000465308
ENST00000461784
ENST00000476394
ENST00000479735
ENST00000484313
ENST00000465070 ENSP00000475502
ENST00000470879 ENSP00000475329
ENST00000462355 ENSP00000475400
ENST00000475115
ENST00000464380
ENST00000539609 ENSP00000443792
ENST00000558170 ENSP00000454157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0019208 phosphatase regulator activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001755 neural crest cell migration
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0030177 positive regulation of Wnt signaling pathway
GO:0043507 positive regulation of JUN kinase activity
GO:0045636 positive regulation of melanocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048023 positive regulation of melanin biosynthetic process
GO:0048066 developmental pigmentation
GO:0048598 embryonic morphogenesis
GO:0097324 melanocyte migration
GO:1903056 regulation of melanosome organization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026872
View Gene Order
ENSBTAG00000012615
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9839
UniGene
RefSeq NM_001171653 NM_014795 XM_006712881 XM_006712882
HUGO HGNC:14881
OMIM 605802
CCDS CCDS2186 CCDS54403
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 9839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca