Homo sapiens Gene: PKIG
Summary
InnateDB Gene IDBG-76749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKIG
Gene Name protein kinase (cAMP-dependent, catalytic) inhibitor gamma
Synonyms PKI-gamma
Species Homo sapiens
Ensembl Gene ENSG00000168734
Encoded Proteins
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:44531785-44624247
Strand Forward strand
Band q13.12
Transcripts
ENST00000372891 ENSP00000361981
ENST00000372892 ENSP00000361983
ENST00000372894 ENSP00000361985
ENST00000372889 ENSP00000361980
ENST00000372887 ENSP00000361978
ENST00000372886 ENSP00000361977
ENST00000349959 ENSP00000338067
ENST00000477390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0007165 signal transduction
GO:0042308 negative regulation of protein import into nucleus
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.472831
RefSeq NM_001281444 NM_001281445 NM_007066 NM_181804 NM_181805
HUGO
OMIM
CCDS CCDS13334
HPRD 05379
IMGT
EMBL
GenPept
RNA Seq Atlas