InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HK1

Summary

InnateDB Gene

IDBG-76783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HK1

Gene Name

hexokinase 1

Synonyms

HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1

Species

Homo sapiens

Ensembl Gene

ENSG00000156515

Encoded Proteins

IDBP-76785

hexokinase 1

IDBP-76789

hexokinase 1

IDBP-76791

hexokinase 1

IDBP-378216

hexokinase 1

IDBP-378228

hexokinase 1

IDBP-378234

hexokinase 1

IDBP-378239

hexokinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:69269984-69401882

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000360289	ENSP00000353433
ENST00000298649	ENSP00000298649
ENST00000359426	ENSP00000352398
ENST00000450646	ENSP00000409761
ENST00000448642	ENSP00000402103
ENST00000421088	ENSP00000398316
ENST00000436817	ENSP00000415949
ENST00000464803
ENST00000480047
ENST00000483077
ENST00000479594
ENST00000476368
ENST00000483054
ENST00000488644
ENST00000493591
ENST00000494253
ENST00000470050

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008865	fructokinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0008219	cell death
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0019318	hexose metabolic process
GO:0044281	small molecule metabolic process
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0055085	transmembrane transport