Homo sapiens Gene: HK1
Summary
InnateDB Gene IDBG-76783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HK1
Gene Name hexokinase 1
Synonyms HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1;
Species Homo sapiens
Ensembl Gene ENSG00000156515
Encoded Proteins
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:69269984-69401882
Strand Forward strand
Band q22.1
Transcripts
ENST00000360289 ENSP00000353433
ENST00000298649 ENSP00000298649
ENST00000359426 ENSP00000352398
ENST00000450646 ENSP00000409761
ENST00000448642 ENSP00000402103
ENST00000421088 ENSP00000398316
ENST00000436817 ENSP00000415949
ENST00000464803
ENST00000480047
ENST00000483077
ENST00000479594
ENST00000476368
ENST00000483054
ENST00000488644
ENST00000493591
ENST00000494253
ENST00000470050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 45 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008865 fructokinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
Biological Process
GO:0001678 cellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0008219 cell death
GO:0008645 hexose transport
GO:0015758 glucose transport
GO:0019318 hexose metabolic process
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005929 cilium
GO:0045121 membrane raft
GO:0097228 sperm principal piece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Myoclonic epilepsy of Lafora pathway
Glucose transport pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fructose and mannose metabolism pathway
Galactose metabolism pathway
Starch and sucrose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
Butirosin and neomycin biosynthesis pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Carbohydrate digestion and absorption pathway
INOH
Fructose Mannose metabolism pathway
Glycolysis Gluconeogenesis pathway
Aminosugars metabolism pathway
PID BIOCARTA
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370365
RefSeq NM_000188 NM_033496 NM_033497 NM_033498 NM_033500 XM_005269735 XM_005269736 XM_005269737
HUGO
OMIM
CCDS CCDS7289 CCDS7290 CCDS7291 CCDS7292
HPRD 00809
IMGT
EMBL
GenPept
RNA Seq Atlas