Homo sapiens Gene: RGS12
Summary
InnateDB Gene IDBG-7983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS12
Gene Name regulator of G-protein signaling 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159788
Encoded Proteins
regulator of G-protein signaling 12
regulator of G-protein signaling 12
regulator of G-protein signaling 12
regulator of G-protein signaling 12
regulator of G-protein signaling 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the \'regulator of G protein signaling\' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:3293028-3439913
Strand Forward strand
Band p16.3
Transcripts
ENST00000344733 ENSP00000339381
ENST00000382788 ENSP00000372238
ENST00000336727 ENSP00000338509
ENST00000338806 ENSP00000342133
ENST00000506631
ENST00000502947
ENST00000514268 ENSP00000424251
ENST00000511805
ENST00000513784
ENST00000506998
ENST00000508158
ENST00000505570
ENST00000512990
ENST00000503041
ENST00000504194
ENST00000512266
ENST00000513991
ENST00000515521
ENST00000510803
ENST00000509746
ENST00000511709
ENST00000507041
ENST00000507246
ENST00000504559
ENST00000509772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0030695 GTPase regulator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527061 Hs.688720 Hs.722474
RefSeq NM_002926 NM_198227 NM_198229 XM_006713905 XM_006713907
HUGO
OMIM
CCDS CCDS3366 CCDS3367 CCDS3368
HPRD 03943
IMGT
EMBL
GenPept
RNA Seq Atlas