InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RGS12

Summary

InnateDB Gene

IDBG-7983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS12

Gene Name

regulator of G-protein signaling 12

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000159788

Encoded Proteins

IDBP-7985

regulator of G-protein signaling 12

IDBP-7987

regulator of G-protein signaling 12

IDBP-7991

regulator of G-protein signaling 12

IDBP-7995

regulator of G-protein signaling 12

IDBP-478543

regulator of G-protein signaling 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the \'regulator of G protein signaling\' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:3293028-3439913

Strand

Forward strand

Band

p16.3

Transcripts

ENST00000344733	ENSP00000339381
ENST00000382788	ENSP00000372238
ENST00000336727	ENSP00000338509
ENST00000338806	ENSP00000342133
ENST00000506631
ENST00000502947
ENST00000514268	ENSP00000424251
ENST00000511805
ENST00000513784
ENST00000506998
ENST00000508158
ENST00000505570
ENST00000512990
ENST00000503041
ENST00000504194
ENST00000512266
ENST00000513991
ENST00000515521
ENST00000510803
ENST00000509746
ENST00000511709
ENST00000507041
ENST00000507246
ENST00000504559
ENST00000509772

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0030695	GTPase regulator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016363	nuclear matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029101

View Gene Order

ENSBTAG00000016714

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.527061 Hs.688720 Hs.722474

RefSeq

NM_002926 NM_198227 NM_198229 XM_006713905 XM_006713907

HUGO

OMIM

CCDS

CCDS3366 CCDS3367 CCDS3368

HPRD

03943

IMGT

EMBL

GenPept

RNA Seq Atlas