Homo sapiens Gene: FN1
Summary
InnateDB Gene IDBG-80237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FN1
Gene Name fibronectin 1
Synonyms CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF;
Species Homo sapiens
Ensembl Gene ENSG00000115414
Encoded Proteins
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
fibronectin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:215360440-215436172
Strand Reverse strand
Band q35
Transcripts
ENST00000357867 ENSP00000350534
ENST00000356005 ENSP00000348285
ENST00000323926 ENSP00000323534
ENST00000359671 ENSP00000352696
ENST00000336916 ENSP00000338200
ENST00000354785 ENSP00000346839
ENST00000421182 ENSP00000394423
ENST00000432072 ENSP00000399538
ENST00000443816 ENSP00000415018
ENST00000446046 ENSP00000410422
ENST00000456923 ENSP00000416139
ENST00000438981 ENSP00000392565
ENST00000426059 ENSP00000398907
ENST00000492816
ENST00000498719
ENST00000494446
ENST00000469569
ENST00000473614
ENST00000480024
ENST00000461974
ENST00000485567
ENST00000460217
ENST00000474036
ENST00000490833
ENST00000480737
ENST00000471193
ENST00000496542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 758 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 758 [view]
Protein-Protein 757 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
Biological Process
GO:0001525 angiogenesis
GO:0002576 platelet degranulation
GO:0006953 acute-phase response
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007596 blood coagulation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010952 positive regulation of peptidase activity
GO:0018149 peptide cross-linking
GO:0022617 extracellular matrix disassembly
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042060 wound healing
GO:0045773 positive regulation of axon extension
GO:0050900 leukocyte migration
Cellular Component
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005615 extracellular space
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016324 apical plasma membrane
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
Degradation of the extracellular matrix pathway
Syndecan interactions pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Response to elevated platelet cytosolic Ca2+ pathway
Platelet Aggregation (Plug Formation) pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Fibronectin matrix formation pathway
p130Cas linkage to MAPK signaling for integrins pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Syndecan-2-mediated signaling events
Beta1 integrin cell surface interactions
Integrins in angiogenesis
VEGFR3 signaling in lymphatic endothelium
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Alpha9 beta1 integrin signaling events
Angiopoietin receptor Tie2-mediated signaling
Syndecan-4-mediated signaling events
Alpha4 beta1 integrin signaling events
Beta3 integrin cell surface interactions
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt P02751
TrEMBL A6YID2 Q53S27 Q7L553 Q9H382
UniProt Splice Variant
Entrez Gene 2335
UniGene Hs.203717 Hs.626165 Hs.629065 Hs.660195
RefSeq NM_002026 NM_054034 NM_212474 NM_212476 NM_212478 NM_212482 XM_005246397 XM_005246399 XM_005246400 XM_005246404 XM_005246406 XM_005246411 XM_005246413 XM_005246415 XM_005246416 XM_005246417
HUGO HGNC:3778
OMIM 135600
CCDS CCDS2399 CCDS2400 CCDS42813 CCDS42814 CCDS46510 CCDS46512
HPRD 00626
IMGT
EMBL AB191261 AB209840 AC012462 AC073284 AF130095 AF312399 AJ276395 AJ320525 AJ320526 AJ320527 AJ535086 AJ849445 AL832202 BC005858 BC117176 BC143763 BT006856 BX537590 BX538017 BX538018 BX538045 BX640608 BX640731 BX640875 BX640920 CH471063 CR749281 CR749316 CR749317 EF550130 M10905 M12549 M14059 M15801 M18177 M18178 M18179 M27589 U41850 U42404 U42455 U42456 U42457 U42458 U42592 U42593 U42594 X02761 X04530 X07717 X07718
GenPept AAA52461 AAA52462 AAA52463 AAA52465 AAA53376 AAA58483 AAD00014 AAD00015 AAD00017 AAD00018 AAD00019 AAD04751 AAD09448 AAD09449 AAD09450 AAG30571 AAG35520 AAH05858 AAI17177 AAI43764 AAP35502 AAX76513 AAY24063 ABR68534 BAD52437 BAD93077 CAA26536 CAB52436 CAB52437 CAC20427 CAC86914 CAC86915 CAC86916 CAD59389 CAD91166 CAD97791 CAD97964 CAD97965 CAD97984 CAE45714 CAE45847 CAE45932 CAE45958 CAH18136 CAH18171 CAH18172 CAH60958 EAW70536
RNA Seq Atlas 2335