InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FN1

Summary

InnateDB Gene

IDBG-80237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FN1

Gene Name

fibronectin 1

Synonyms

CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF

Species

Homo sapiens

Ensembl Gene

ENSG00000115414

Encoded Proteins

IDBP-80239

fibronectin 1

IDBP-80241

fibronectin 1

IDBP-80243

fibronectin 1

IDBP-80245

fibronectin 1

IDBP-80247

fibronectin 1

IDBP-80257

fibronectin 1

IDBP-388794

fibronectin 1

IDBP-388795

fibronectin 1

IDBP-388796

fibronectin 1

IDBP-388797

fibronectin 1

IDBP-388798

fibronectin 1

IDBP-388799

fibronectin 1

IDBP-388800

fibronectin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:215360440-215436172

Strand

Reverse strand

Band

q35

Transcripts

ENST00000357867	ENSP00000350534
ENST00000356005	ENSP00000348285
ENST00000323926	ENSP00000323534
ENST00000359671	ENSP00000352696
ENST00000336916	ENSP00000338200
ENST00000354785	ENSP00000346839
ENST00000421182	ENSP00000394423
ENST00000432072	ENSP00000399538
ENST00000443816	ENSP00000415018
ENST00000446046	ENSP00000410422
ENST00000456923	ENSP00000416139
ENST00000438981	ENSP00000392565
ENST00000426059	ENSP00000398907
ENST00000492816
ENST00000498719
ENST00000494446
ENST00000469569
ENST00000473614
ENST00000480024
ENST00000461974
ENST00000485567
ENST00000460217
ENST00000474036
ENST00000490833
ENST00000480737
ENST00000471193
ENST00000496542

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 758 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	758 [view]
Protein-Protein	757 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0016504	peptidase activator activity

Biological Process

GO:0001525	angiogenesis
GO:0002576	platelet degranulation
GO:0006953	acute-phase response
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007161	calcium-independent cell-matrix adhesion
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0009611	response to wounding
GO:0010952	positive regulation of peptidase activity
GO:0018149	peptide cross-linking
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042060	wound healing
GO:0045773	positive regulation of axon extension
GO:0050900	leukocyte migration

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016324	apical plasma membrane
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026193

View Gene Order

ENSBTAG00000008300

Not yet available

Pathways

NETPATH

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_15443

GRB2:SOS provides linkage to MAPK signaling for Integrins pathway

REACT_15381

p130Cas linkage to MAPK signaling for integrins pathway

REACT_15523

Integrin alphaIIb beta3 signaling pathway

REACT_278

Platelet Aggregation (Plug Formation) pathway

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_13552

Integrin cell surface interactions pathway

REACT_150331

Molecules associated with elastic fibres pathway

REACT_150366

Elastic fibre formation pathway

REACT_160131

Fibronectin matrix formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_163942

Syndecan interactions pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_163906

ECM proteoglycans pathway

REACT_163874

Non-integrin membrane-ECM interactions pathway

REACT_604

Hemostasis pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04512

ECM-receptor interaction pathway

hsa05222

Small cell lung cancer pathway

hsa04510

Focal adhesion pathway

hsa05200

Pathways in cancer pathway

hsa05146

Amoebiasis pathway

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

INOH website

Integrin signaling pathway pathway

PID NCI

syndecan_2_pathway

Syndecan-2-mediated signaling events

integrin1_pathway

Beta1 integrin cell surface interactions

avb3_integrin_pathway

Integrins in angiogenesis

lymphangiogenesis_pathway

VEGFR3 signaling in lymphatic endothelium

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

integrin_a9b1_pathway

Alpha9 beta1 integrin signaling events

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

syndecan_4_pathway

Syndecan-4-mediated signaling events

integrin_a4b1_pathway

Alpha4 beta1 integrin signaling events

integrin3_pathway

Beta3 integrin cell surface interactions

integrin5_pathway

Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Cross-References

SwissProt

P02751

TrEMBL

A6YID6 Q53S27 Q7L553 Q9H382

UniProt Splice Variant

Entrez Gene

2335

UniGene

Hs.203717 Hs.626165 Hs.629065 Hs.660195

RefSeq

NM_212482 XM_005246397 NM_002026 NM_054034 NM_212474 NM_212476 NM_212478 XM_005246399 XM_005246400 XM_005246404 XM_005246406 XM_005246411 XM_005246413 XM_005246415 XM_005246416 XM_005246417

HUGO

HGNC:3778

OMIM

135600

CCDS

CCDS42814 CCDS2399 CCDS2400 CCDS42813 CCDS46510 CCDS46512

HPRD

00626

IMGT

EMBL

AB191261 AB209840 AC012462 AC073284 AF130095 AF312399 AJ276395 AJ320525 AJ320526 AJ320527 AJ535086 AJ849445 AL832202 BC005858 BC117176 BC143763 BT006856 BX537590 BX538017 BX538018 BX538045 BX640608 BX640731 BX640875 BX640920 CH471063 CR749281 CR749316 CR749317 EF550134 M10905 M12549 M14059 M15801 M18177 M18178 M18179 M27589 U41850 U42404 U42455 U42456 U42457 U42458 U42592 U42593 U42594 X02761 X04530 X07717 X07718

GenPept

AAA52461 AAA52462 AAA52463 AAA52465 AAA53376 AAA58483 AAD00014 AAD00015 AAD00017 AAD00018 AAD00019 AAD04751 AAD09448 AAD09449 AAD09450 AAG30571 AAG35520 AAH05858 AAI17177 AAI43764 AAP35502 AAX76513 AAY24063 ABR68538 BAD52437 BAD93077 CAA26536 CAB52436 CAB52437 CAC20427 CAC86914 CAC86915 CAC86916 CAD59389 CAD91166 CAD97791 CAD97964 CAD97965 CAD97984 CAE45714 CAE45847 CAE45932 CAE45958 CAH18136 CAH18171 CAH18172 CAH60958 EAW70536

RNA Seq Atlas

2335