InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RGS19

Summary

InnateDB Gene

IDBG-87816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS19

Gene Name

regulator of G-protein signaling 19

Synonyms

GAIP; RGSGAIP

Species

Homo sapiens

Ensembl Gene

ENSG00000171700

Encoded Proteins

IDBP-87818

regulator of G-protein signaling 19

IDBP-240357

regulator of G-protein signaling 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:64073181-64079988

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000332298	ENSP00000333194
ENST00000395042	ENSP00000378483
ENST00000493165
ENST00000479996

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle