Version 5.4
Homo sapiens Gene: HAGH
Summary
InnateDB Gene IDBG-9334.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAGH
Gene Name hydroxyacylglutathione hydrolase
Synonyms GLO2; GLX2; GLXII; HAGH1
Species Homo sapiens
Ensembl Gene ENSG00000063854
Encoded Proteins
IDBP-235557
hydroxyacylglutathione hydrolase
IDBP-235559
hydroxyacylglutathione hydrolase
IDBP-363825
hydroxyacylglutathione hydrolase
IDBP-746935
IDBP-749716
IDBP-746449
IDBP-753499
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1795620-1827194
Strand Reverse strand
Band p13.3
Transcripts
ENST00000397356 ENSP00000380514
ENST00000397353 ENSP00000380511
ENST00000455446 ENSP00000406552
ENST00000566644 ENSP00000457986
ENST00000564445 ENSP00000455355
ENST00000567190
ENST00000567398
ENST00000565097
ENST00000566709 ENSP00000455422
ENST00000569700
ENST00000564518
ENST00000569339 ENSP00000455970
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006750 glutathione biosynthetic process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024158
View Gene Order
ENSBTAG00000019998
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00620
Pyruvate metabolism pathway
INOH
INOH website
Pyruvate metabolism pathway
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt Q16775
TrEMBL H3BQW8 H3BV79
UniProt Splice Variant
Entrez Gene 3029
UniGene Hs.157394
RefSeq NM_001040427 NM_001286249 NM_005326
HUGO HGNC:4805
OMIM 138760
CCDS CCDS32366 CCDS10447 CCDS66900
HPRD 00731
IMGT
EMBL AC012180 AE006639 AK290155 AK298174 AK299173 BC000840 BC002627 X90999
GenPept AAH00840 AAH02627 AAK61294 BAF82844 BAG60445 BAG61219 CAA62483
RNA Seq Atlas 3029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca