InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYNCRIP

Summary

InnateDB Gene

IDBG-94027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNCRIP

Gene Name

synaptotagmin binding, cytoplasmic RNA interacting protein

Synonyms

GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1; NSAP1; PP68

Species

Homo sapiens

Ensembl Gene

ENSG00000135316

Encoded Proteins

IDBP-94031

synaptotagmin binding, cytoplasmic RNA interacting protein

IDBP-94033

synaptotagmin binding, cytoplasmic RNA interacting protein

IDBP-385068

synaptotagmin binding, cytoplasmic RNA interacting protein

IDBP-478955

synaptotagmin binding, cytoplasmic RNA interacting protein

IDBP-808578

synaptotagmin binding, cytoplasmic RNA interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:85607785-85643792

Strand

Reverse strand

Band

q14.3

Transcripts

ENST00000355238	ENSP00000347380
ENST00000369622	ENSP00000358635
ENST00000444272	ENSP00000397782
ENST00000503906	ENSP00000426494
ENST00000616122	ENSP00000484577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	160 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0016032	viral process
GO:0017148	negative regulation of translation
GO:0070934	CRD-mediated mRNA stabilization
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome
GO:0071204	histone pre-mRNA 3'end processing complex
GO:0097452	GAIT complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032423

View Gene Order

ENSBTAG00000006672

Not yet available

Cross-References

SwissProt

O60506

TrEMBL

F6UXX1

UniProt Splice Variant

Entrez Gene

10492

UniGene

Hs.485877 Hs.571177 Hs.602341 Hs.609969 Hs.715430

RefSeq

NM_001159675 NM_006372 XM_005248637 NM_001159673 NM_001159674 NM_001159676 NM_001159677 NM_001253771 XM_005248635

HUGO

HGNC:16918

OMIM

CCDS

CCDS5005 CCDS55041 CCDS75491

HPRD

06734

IMGT

EMBL

AF037448 AF155568 AK222776 AL136082 AY034481 AY034482 AY034483 BC015575 BC032643 BC040844 CH471051

GenPept

AAC12926 AAD38198 AAH15575 AAH32643 AAH40844 AAK59703 AAK59704 AAK59705 BAD96496 CAI20446 CAI20447 EAW48625 EAW48626 EAW48629 EAW48630

RNA Seq Atlas

10492