Homo sapiens Gene: SYNCRIP
Summary
InnateDB Gene IDBG-94027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNCRIP
Gene Name synaptotagmin binding, cytoplasmic RNA interacting protein
Synonyms GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1; NSAP1; PP68;
Species Homo sapiens
Ensembl Gene ENSG00000135316
Encoded Proteins
synaptotagmin binding, cytoplasmic RNA interacting protein
synaptotagmin binding, cytoplasmic RNA interacting protein
synaptotagmin binding, cytoplasmic RNA interacting protein
synaptotagmin binding, cytoplasmic RNA interacting protein
synaptotagmin binding, cytoplasmic RNA interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:85607785-85643792
Strand Reverse strand
Band q14.3
Transcripts
ENST00000355238 ENSP00000347380
ENST00000369622 ENSP00000358635
ENST00000444272 ENSP00000397782
ENST00000503906 ENSP00000426494
ENST00000616122 ENSP00000484577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 160 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008143 poly(A) binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001649 osteoblast differentiation
GO:0006396 RNA processing
GO:0008380 RNA splicing
GO:0016032 viral process
GO:0017148 negative regulation of translation
GO:0070934 CRD-mediated mRNA stabilization
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070937 CRD-mediated mRNA stability complex
GO:0071013 catalytic step 2 spliceosome
GO:0071204 histone pre-mRNA 3'end processing complex
GO:0097452 GAIT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.485877 Hs.571177 Hs.602341 Hs.609969 Hs.715430
RefSeq NM_001159673 NM_001159674 NM_001159675 NM_001159676 NM_001159677 NM_001253771 NM_006372 XM_005248635 XM_005248637
HUGO
OMIM
CCDS CCDS5005 CCDS55041 CCDS75491
HPRD 06734
IMGT
EMBL
GenPept
RNA Seq Atlas