Version 5.4
Homo sapiens Gene: PKIB
Summary
InnateDB Gene IDBG-96012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKIB
Gene Name protein kinase (cAMP-dependent, catalytic) inhibitor beta
Synonyms PRKACN2
Species Homo sapiens
Ensembl Gene ENSG00000135549
Encoded Proteins
IDBP-96014
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-96016
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-96018
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-96020
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-96022
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-245553
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-245555
protein kinase (cAMP-dependent, catalytic) inhibitor beta
IDBP-808730
protein kinase (cAMP-dependent, catalytic) inhibitor beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122471917-122726373
Strand Forward strand
Band q22.31
Transcripts
ENST00000368452 ENSP00000357437
ENST00000368448 ENSP00000357433
ENST00000258014 ENSP00000258014
ENST00000354275 ENSP00000346227
ENST00000368446 ENSP00000357431
ENST00000392491 ENSP00000376281
ENST00000392490 ENSP00000376280
ENST00000607474
ENST00000608895
ENST00000618977
ENST00000615438 ENSP00000480824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019876
View Gene Order
ENSBTAG00000004394
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595503 Hs.734380
RefSeq NM_001270393 NM_001270394 NM_001270395 NM_032471 NM_181794 NM_181795
HUGO
OMIM
CCDS CCDS5126 CCDS59033
HPRD 06075
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca