InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDCA8

Summary

InnateDB Gene

IDBG-96468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDCA8

Gene Name

cell division cycle associated 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134690

Encoded Proteins

IDBP-96470

cell division cycle associated 8

IDBP-96472

cell division cycle associated 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:37692418-37709719

Strand

Forward strand

Band

p34.3

Transcripts

ENST00000373055	ENSP00000362146
ENST00000327331	ENSP00000316121

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000089	mitotic metaphase
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0051276	chromosome organization

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005819	spindle
GO:0005829	cytosol
GO:0010369	chromocenter
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0043234	protein complex
GO:0045171	intercellular bridge