Homo sapiens Gene: CDCA8
Summary
InnateDB Gene IDBG-96468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCA8
Gene Name cell division cycle associated 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134690
Encoded Proteins
cell division cycle associated 8
cell division cycle associated 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37692418-37709719
Strand Forward strand
Band p34.3
Transcripts
ENST00000373055 ENSP00000362146
ENST00000327331 ENSP00000316121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000089 mitotic metaphase
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0051276 chromosome organization
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005819 spindle
GO:0005829 cytosol
GO:0010369 chromocenter
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:0043234 protein complex
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSLP pathway
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora B signaling
Cross-References
SwissProt Q53HL2
TrEMBL
UniProt Splice Variant
Entrez Gene 55143
UniGene Hs.524571
RefSeq NM_001256875 NM_018101
HUGO HGNC:14629
OMIM 609977
CCDS CCDS424
HPRD 13017
IMGT
EMBL AK001330 AK022104 AK022606 AK222549 AK222568 AY508815 BC000703 BC001651 BC008079 BC016944 BG354581 CH471059
GenPept AAH00703 AAH01651 AAH08079 AAH16944 AAR91699 BAA91629 BAB13961 BAB14125 BAD96269 BAD96288 EAX07324 EAX07325
RNA Seq Atlas 55143