Version 5.4
Mus musculus Gene: Iqcb1
Summary
InnateDB Gene IDBG-158489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iqcb1
Gene Name IQ calmodulin-binding motif containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022837
Encoded Proteins
IDBP-158491
IQ calmodulin-binding motif containing 1
IDBP-250965
IQ calmodulin-binding motif containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173226:
This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:36828385-36872721
Strand Forward strand
Band B3
Transcripts
ENSMUST00000023535 ENSMUSP00000023535
ENSMUST00000114819 ENSMUSP00000110467
ENSMUST00000146272
ENSMUST00000137076
ENSMUST00000142619
ENSMUST00000129123
ENSMUST00000153373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
They are also associated with 166 interaction(s) predicted by orthology.
Experimentally validated
Total 165 [view]
Protein-Protein 165 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 166 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0019899 enzyme binding
Biological Process
GO:0042384 cilium assembly
GO:0045494 photoreceptor cell maintenance
GO:0048496 maintenance of organ identity
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0015630 microtubule cytoskeleton
GO:0032391 photoreceptor connecting cilium
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000173226
View Gene Order
ENSBTAG00000013069
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.222934 Mm.448362
RefSeq NM_177128 XM_006522247 XM_006522248 XM_006522249 XM_006522250
OMIM
CCDS CCDS28157
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca